forever healthy
  • Home
    • The ​Opportunity
    • Our Approach
    • The Foundation
    • Meet the Team
    • Our Office
  • Initiatives
    • Rejuvenation Now
    • Maximizing Health
    • Longevity Strategy
    • Undoing Aging Conference
    • Funding Research
    • Supporting Startups
    • Online Meetup
  • Careers
  • News
  • Videos
  • Knowledge Base

News

New research project: Retrolytics - Cells with active retrobiome as a rejuventation treatment

9/22/2020

 
Picture
Happy to introduce our third supported research project of 2020: Dr. Andrei Gudkov's research on Cells with active retrobiome as a rejuvenation treatment at Roswell Park Cancer Institute. 

Nearly half of the mammalian genome is comprised of a “retrobiome” including millions of copies of including long and short interspersed virus-like repetitive elements (LINEs). Aging-related failure of silencing mechanisms can result in LINE activation and such LINE active cells –characterized by an expression of interferon (IFN) – may be a mayor contributor to systemic aging. However, the relationship between LINE activation and aging is still extremely poorly understood.

Our specific aims are: (1) to create an “atlas” of IFN expression (tissue localization, cell type) in tissues of wild type mice of different ages under normal and aging-accelerating conditions (total body irradiation, obesity), in mice with short life spans and genetically desilenced retrobiomes (Sirt6- and p53-deficiency), during spontaneous carcinogenesis (mice genetically predisposed to breast and prostate cancer) and under rejuvenation treatments (e.g., rapamycin, senolytic compounds); and (2) to determine the rejuventation effect of pharmacological eradication of IFN-positive cells in the context of normal and accelerated aging and in mice genetically predisposed to premature aging and spontaneous cancer development.
​

Successful completion of these aims will provide insight into the role of retrobiome-mediated IFN response activation as a regulator of aging and provide proof-of-concept for a new rejuvenation approach, “retrolytic” therapy, based on eradication of cells with retrobiome and IFN response activation.

Comments are closed.

​Looking for a career? 
Join the team!
Stay updated on all our initiatives

Facebook Page
​
Facebook Group

Twitter
Online Meetup
​Undoing Aging Conference
Imprint
Disclaimer
​
Privacy
  • Home
    • The ​Opportunity
    • Our Approach
    • The Foundation
    • Meet the Team
    • Our Office
  • Initiatives
    • Rejuvenation Now
    • Maximizing Health
    • Longevity Strategy
    • Undoing Aging Conference
    • Funding Research
    • Supporting Startups
    • Online Meetup
  • Careers
  • News
  • Videos
  • Knowledge Base